From I-71 Southbound
Take Third Street exit to Broadway. Turn right on Broadway. Turn right on Fifth Street. Turn right on Pike Street. Museum is second building on left.  

From I-71/I-75 Northbound
Cross the bridge over the Ohio River. Take Fifth Street exit and follow through light at Broadway. Turn right at next light on Pike Street. Museum is second building on left.  

From I-75 Southbound
Take Fifth Street exit and follow through light at Broadway. Turn right at next light on Pike Street. Museum is second building on left.  

From I-471 Northbound
Take the Sixth Street exit. Turn left on Sycamore. Turn left on Fifth Street. Turn right on Pike Street. Museum is second building on left.  

From Columbia Parkway
Take Columbia Parkway to downtown. Turn left on Pike Street. The Museum is second building on left.  

From Central Parkway
Take Central Parkway to Eggleston (behind Justice Center). Right on Eggleston to Third Street. Right on Third Street to Pike Street. Museum is second building on right.